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sr1  (Selleck Chemicals)


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    Selleck Chemicals sr1
    Sr1, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 94/100, based on 61 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/sr1/StemRegenin+1/10__1158_slash_1078___0432__ccr___25___1444-122-44-46
    Average 94 stars, based on 61 article reviews
    sr1 - by Bioz Stars, 2026-10
    94/100 stars

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    Cell Culture:

    Article Title: A novel potent and selective GCN2 inhibitor, APL-4098, has anti-leukemic activity through dysregulation of mitochondrial function
    Article Snippet: .. Cells were cultured at 0.5-1x106 cells/ml in SFEMII medium (Stemcell Technologies, #09655), supplemented with 1% Antibiotic-Antimycotic (Gibco, 15240062), TPO (100ng/ml; Peprotech, 300-18), FLT3L (100ng/ml; Peprotech, 300-19), SCF (100ng/ml; Peprotech, 300-07), IL-6 (100ng/ml; Peprotech, 200-06), IL-3 (100ng/ml; Peprotech, 200-03), UM729 (35nM; Stemcell Technologies, 72332), and SR1 (750nM, Selleck Chemicals LLC, S2858). ..

    Article Title: MDS-associated SF3B1 mutations promote aberrant fate choice of hematopoietic stem cell via mis-splicing of mediator kinase module component CDK8
    Article Snippet: Human umbilical cord blood CD34 + cells (STEMCELL Technologies) and GCSF-mobilized adult CD34 + cells (Fred Hutch Co-Operative Center for Excellence on Hematology (CCEH)) were thawed according to the manufacturer’s instructions. .. Cells were cultured in SFEM-II (STEMCELL Technologies) supplemented with recombinant human cytokines (50 ng/mL SCF, 50 ng/mL FLT3L, 50 ng/mL TPO; all from Peprotech), 10 μg/mL LDL (STEMCELL Technologies), 500 nM SR1 (Selleck Chem.), 1 μM UM729 (STEMCELL Technologies) for 24 hours prior to nucleofection. .. K562, 293T, HNT34, and Nalm6 cells were cultured in base media (IMDM, DMEM, and RPMI, respectively) supplemented with penicillin-streptomycin (100 U/mL, Gibco, No. 15140122), Glutamax (1%, Gibco, No. 35050061) and heat-inactivated FBS (10%: K562, 293T, NALM6, 20%: HNT34).

    Article Title: Path of differentiation defines human macrophage identity
    Article Snippet: Both processes utilized LS columns (Miltenyi) and a QuadroMACSTM Separator (Miltenyi) and followed manufacturer recommendations for concentration of microbeads and antibodies. .. Macrophages were then split into multiple wells and cultured in X-VIVOTM-15 supplemented with 50ng/mL M-CSF or GM-CSF and 1 μM of SR1 (Selleck), CH-223191 (Selleck), or FICZ (MedChemExpress). .. In vitro-differentiated macrophages were selected by CD14 microbeads as previously described.

    Article Title: DNA methyltransferase Dnmt3ba-mediated epigenetic modulation of Integrin signaling is essential for hematopoietic stem and progenitor cell development.
    Article Snippet: The cells were then digested into single cells by Accutase cell dissociation reagent (Sigma, A6964) and resuspended in SPELS differentiation medium, as previously reported5. .. The EBs were cultured in a medium containing 10 ng/ml each of rh SCF, rh TPO (PeproTech, 300-18), rh FGF2, rh IGF1, rh IGF2, along with 100 nM RETA and 20 nM SR1 (Selleck, S2858). .. Then the mesoderm was induced on day (D) 0 of differentiation by a combination of 4 μM CHIR99021 (Selleck, S2924), 30 ng/ml Activin A (MCE, HY-P70311AF), 20 ng/ml recombinant human (rh) FGF2 (PeproTech, AF-100-18B), and 1 μM ROCK inhibitor (Selleck, S6390).

    Article Title: Long-term engrafting multilineage hematopoietic cells differentiated from human induced pluripotent stem cells.
    Article Snippet: .. EBs were cultured in 10 ng ml−1 each of rh SCF, rh TPO (PeproTech), rh FGF2, rh IGF1, rh IGF2 and 100 nM RETA and 20 nM SR1 (Selleck Chem). ..

    Recombinant:

    Article Title: MDS-associated SF3B1 mutations promote aberrant fate choice of hematopoietic stem cell via mis-splicing of mediator kinase module component CDK8
    Article Snippet: Human umbilical cord blood CD34 + cells (STEMCELL Technologies) and GCSF-mobilized adult CD34 + cells (Fred Hutch Co-Operative Center for Excellence on Hematology (CCEH)) were thawed according to the manufacturer’s instructions. .. Cells were cultured in SFEM-II (STEMCELL Technologies) supplemented with recombinant human cytokines (50 ng/mL SCF, 50 ng/mL FLT3L, 50 ng/mL TPO; all from Peprotech), 10 μg/mL LDL (STEMCELL Technologies), 500 nM SR1 (Selleck Chem.), 1 μM UM729 (STEMCELL Technologies) for 24 hours prior to nucleofection. .. K562, 293T, HNT34, and Nalm6 cells were cultured in base media (IMDM, DMEM, and RPMI, respectively) supplemented with penicillin-streptomycin (100 U/mL, Gibco, No. 15140122), Glutamax (1%, Gibco, No. 35050061) and heat-inactivated FBS (10%: K562, 293T, NALM6, 20%: HNT34).

    other:

    Article Title: DNA methyltransferase Dnmt3ba-mediated epigenetic modulation of Integrin signaling is essential for hematopoietic stem and progenitor cell development
    Article Snippet: On D3, the medium was supplemented with 20 ng/ml rh BMP4 (PeproTech, 120-05ET), 2 μM RETA, 150 ng/ml rh VEGF, 20 ng/ml rh FGF2, 10 ng/ml rh IGF2 (PeproTech, 100-12) and 10 ng/ml rh IGF1 (PeproTech, 100-11).



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    a , STRING analysis of protein-protein interaction network of transcription factors (TFs) induced after conditioning lesion of DRG. b , qRT-PCR of AhR target genes in DRGs from adult mice treated with ITE (10 mg/kg i.p.) or vehicle. n = 3 DRGs from 3 mice. Unpaired two-tailed t -test. c , qRT-PCR shows downregulation of AhR target genes 48 h after siRNA knockdown of Ahr . n = 3 cultures for Cyp1b1 , n = 4 for the rest. Unpaired two-tailed t -test. d , Heatmap of Ahr , Arnt , and Hif1a expression across cell types of the mouse nervous system. e , IF of adult primary DRG neurons for TUJ1 + neurites. ITE treatment: n = 74 neurons (vehicle), 100 (ITE), from 2 mice. CH: n = 120 neurons (vehicle), 188 (CH), from 2 mice. Median and quartiles shown. Mann-Whitney two-tailed test. f , Cultures of neonatal cortical neurons. Mean longest neurite from n = 19 random fields for vehicle, 22 for ITE, 20 for CH, and 22 for <t>SR1</t> across independent cultures from 2 mice. Violin plots show median and quartiles. One-way ANOVA with Dunnett’s correction. g-i , Paradigm of induced neurons (iNs) derivation and AhR agonist/antagonist treatment ( g ). IF images show Norisoboldine (Nor) treatment reduced neurite length, whereas CH-223191 (CH) enhanced outgrowth ( h ). n = 83 (Veh), 90 (Nor), and 106 (CH) cells. One-way ANOVA with Dunnett’s correction. Violin plots show median and quartiles. Box plots of neurite length (median and quartiles) after 18 hr of treatment ( i ). n = 70 –116 neurons. Highlighted conditions (Nor, CH) correspond to ( h ). Kruskal-Wallis test with Dunn’s correction; only significant P values shown. j , Left, schematic of high-throughput screen for neurite growth-promoting compounds in adult cortical neurons (Sefiani et al. ). Right, quantification of AhR antagonist SR1 effects on neurite growth. Each data point represents mean of >150 neurons (with neurites ≥ 10 μm) from a single well. n = 2–6 wells per group. Mean ± s.e.m. Unpaired two-tailed Student’s t -test. Data are mean ± s.e.m.
    Sr1, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    sr1  (Selleck Chemicals)
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    a , STRING analysis of protein-protein interaction network of transcription factors (TFs) induced after conditioning lesion of DRG. b , qRT-PCR of AhR target genes in DRGs from adult mice treated with ITE (10 mg/kg i.p.) or vehicle. n = 3 DRGs from 3 mice. Unpaired two-tailed t -test. c , qRT-PCR shows downregulation of AhR target genes 48 h after siRNA knockdown of Ahr . n = 3 cultures for Cyp1b1 , n = 4 for the rest. Unpaired two-tailed t -test. d , Heatmap of Ahr , Arnt , and Hif1a expression across cell types of the mouse nervous system. e , IF of adult primary DRG neurons for TUJ1 + neurites. ITE treatment: n = 74 neurons (vehicle), 100 (ITE), from 2 mice. CH: n = 120 neurons (vehicle), 188 (CH), from 2 mice. Median and quartiles shown. Mann-Whitney two-tailed test. f , Cultures of neonatal cortical neurons. Mean longest neurite from n = 19 random fields for vehicle, 22 for ITE, 20 for CH, and 22 for <t>SR1</t> across independent cultures from 2 mice. Violin plots show median and quartiles. One-way ANOVA with Dunnett’s correction. g-i , Paradigm of induced neurons (iNs) derivation and AhR agonist/antagonist treatment ( g ). IF images show Norisoboldine (Nor) treatment reduced neurite length, whereas CH-223191 (CH) enhanced outgrowth ( h ). n = 83 (Veh), 90 (Nor), and 106 (CH) cells. One-way ANOVA with Dunnett’s correction. Violin plots show median and quartiles. Box plots of neurite length (median and quartiles) after 18 hr of treatment ( i ). n = 70 –116 neurons. Highlighted conditions (Nor, CH) correspond to ( h ). Kruskal-Wallis test with Dunn’s correction; only significant P values shown. j , Left, schematic of high-throughput screen for neurite growth-promoting compounds in adult cortical neurons (Sefiani et al. ). Right, quantification of AhR antagonist SR1 effects on neurite growth. Each data point represents mean of >150 neurons (with neurites ≥ 10 μm) from a single well. n = 2–6 wells per group. Mean ± s.e.m. Unpaired two-tailed Student’s t -test. Data are mean ± s.e.m.
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    a , STRING analysis of protein-protein interaction network of transcription factors (TFs) induced after conditioning lesion of DRG. b , qRT-PCR of AhR target genes in DRGs from adult mice treated with ITE (10 mg/kg i.p.) or vehicle. n = 3 DRGs from 3 mice. Unpaired two-tailed t -test. c , qRT-PCR shows downregulation of AhR target genes 48 h after siRNA knockdown of Ahr . n = 3 cultures for Cyp1b1 , n = 4 for the rest. Unpaired two-tailed t -test. d , Heatmap of Ahr , Arnt , and Hif1a expression across cell types of the mouse nervous system. e , IF of adult primary DRG neurons for TUJ1 + neurites. ITE treatment: n = 74 neurons (vehicle), 100 (ITE), from 2 mice. CH: n = 120 neurons (vehicle), 188 (CH), from 2 mice. Median and quartiles shown. Mann-Whitney two-tailed test. f , Cultures of neonatal cortical neurons. Mean longest neurite from n = 19 random fields for vehicle, 22 for ITE, 20 for CH, and 22 for <t>SR1</t> across independent cultures from 2 mice. Violin plots show median and quartiles. One-way ANOVA with Dunnett’s correction. g-i , Paradigm of induced neurons (iNs) derivation and AhR agonist/antagonist treatment ( g ). IF images show Norisoboldine (Nor) treatment reduced neurite length, whereas CH-223191 (CH) enhanced outgrowth ( h ). n = 83 (Veh), 90 (Nor), and 106 (CH) cells. One-way ANOVA with Dunnett’s correction. Violin plots show median and quartiles. Box plots of neurite length (median and quartiles) after 18 hr of treatment ( i ). n = 70 –116 neurons. Highlighted conditions (Nor, CH) correspond to ( h ). Kruskal-Wallis test with Dunn’s correction; only significant P values shown. j , Left, schematic of high-throughput screen for neurite growth-promoting compounds in adult cortical neurons (Sefiani et al. ). Right, quantification of AhR antagonist SR1 effects on neurite growth. Each data point represents mean of >150 neurons (with neurites ≥ 10 μm) from a single well. n = 2–6 wells per group. Mean ± s.e.m. Unpaired two-tailed Student’s t -test. Data are mean ± s.e.m.
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    kalle gehring  (Addgene inc)
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    a , STRING analysis of protein-protein interaction network of transcription factors (TFs) induced after conditioning lesion of DRG. b , qRT-PCR of AhR target genes in DRGs from adult mice treated with ITE (10 mg/kg i.p.) or vehicle. n = 3 DRGs from 3 mice. Unpaired two-tailed t -test. c , qRT-PCR shows downregulation of AhR target genes 48 h after siRNA knockdown of Ahr . n = 3 cultures for Cyp1b1 , n = 4 for the rest. Unpaired two-tailed t -test. d , Heatmap of Ahr , Arnt , and Hif1a expression across cell types of the mouse nervous system. e , IF of adult primary DRG neurons for TUJ1 + neurites. ITE treatment: n = 74 neurons (vehicle), 100 (ITE), from 2 mice. CH: n = 120 neurons (vehicle), 188 (CH), from 2 mice. Median and quartiles shown. Mann-Whitney two-tailed test. f , Cultures of neonatal cortical neurons. Mean longest neurite from n = 19 random fields for vehicle, 22 for ITE, 20 for CH, and 22 for <t>SR1</t> across independent cultures from 2 mice. Violin plots show median and quartiles. One-way ANOVA with Dunnett’s correction. g-i , Paradigm of induced neurons (iNs) derivation and AhR agonist/antagonist treatment ( g ). IF images show Norisoboldine (Nor) treatment reduced neurite length, whereas CH-223191 (CH) enhanced outgrowth ( h ). n = 83 (Veh), 90 (Nor), and 106 (CH) cells. One-way ANOVA with Dunnett’s correction. Violin plots show median and quartiles. Box plots of neurite length (median and quartiles) after 18 hr of treatment ( i ). n = 70 –116 neurons. Highlighted conditions (Nor, CH) correspond to ( h ). Kruskal-Wallis test with Dunn’s correction; only significant P values shown. j , Left, schematic of high-throughput screen for neurite growth-promoting compounds in adult cortical neurons (Sefiani et al. ). Right, quantification of AhR antagonist SR1 effects on neurite growth. Each data point represents mean of >150 neurons (with neurites ≥ 10 μm) from a single well. n = 2–6 wells per group. Mean ± s.e.m. Unpaired two-tailed Student’s t -test. Data are mean ± s.e.m.
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    Average 93 stars, based on 1 article reviews
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    aryl hydrocarbon receptor inhibitor sr1  (Selleck Chemicals)
    94
    Selleck Chemicals aryl hydrocarbon receptor inhibitor sr1
    a , STRING analysis of protein-protein interaction network of transcription factors (TFs) induced after conditioning lesion of DRG. b , qRT-PCR of AhR target genes in DRGs from adult mice treated with ITE (10 mg/kg i.p.) or vehicle. n = 3 DRGs from 3 mice. Unpaired two-tailed t -test. c , qRT-PCR shows downregulation of AhR target genes 48 h after siRNA knockdown of Ahr . n = 3 cultures for Cyp1b1 , n = 4 for the rest. Unpaired two-tailed t -test. d , Heatmap of Ahr , Arnt , and Hif1a expression across cell types of the mouse nervous system. e , IF of adult primary DRG neurons for TUJ1 + neurites. ITE treatment: n = 74 neurons (vehicle), 100 (ITE), from 2 mice. CH: n = 120 neurons (vehicle), 188 (CH), from 2 mice. Median and quartiles shown. Mann-Whitney two-tailed test. f , Cultures of neonatal cortical neurons. Mean longest neurite from n = 19 random fields for vehicle, 22 for ITE, 20 for CH, and 22 for <t>SR1</t> across independent cultures from 2 mice. Violin plots show median and quartiles. One-way ANOVA with Dunnett’s correction. g-i , Paradigm of induced neurons (iNs) derivation and AhR agonist/antagonist treatment ( g ). IF images show Norisoboldine (Nor) treatment reduced neurite length, whereas CH-223191 (CH) enhanced outgrowth ( h ). n = 83 (Veh), 90 (Nor), and 106 (CH) cells. One-way ANOVA with Dunnett’s correction. Violin plots show median and quartiles. Box plots of neurite length (median and quartiles) after 18 hr of treatment ( i ). n = 70 –116 neurons. Highlighted conditions (Nor, CH) correspond to ( h ). Kruskal-Wallis test with Dunn’s correction; only significant P values shown. j , Left, schematic of high-throughput screen for neurite growth-promoting compounds in adult cortical neurons (Sefiani et al. ). Right, quantification of AhR antagonist SR1 effects on neurite growth. Each data point represents mean of >150 neurons (with neurites ≥ 10 μm) from a single well. n = 2–6 wells per group. Mean ± s.e.m. Unpaired two-tailed Student’s t -test. Data are mean ± s.e.m.
    Aryl Hydrocarbon Receptor Inhibitor Sr1, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    a , STRING analysis of protein-protein interaction network of transcription factors (TFs) induced after conditioning lesion of DRG. b , qRT-PCR of AhR target genes in DRGs from adult mice treated with ITE (10 mg/kg i.p.) or vehicle. n = 3 DRGs from 3 mice. Unpaired two-tailed t -test. c , qRT-PCR shows downregulation of AhR target genes 48 h after siRNA knockdown of Ahr . n = 3 cultures for Cyp1b1 , n = 4 for the rest. Unpaired two-tailed t -test. d , Heatmap of Ahr , Arnt , and Hif1a expression across cell types of the mouse nervous system. e , IF of adult primary DRG neurons for TUJ1 + neurites. ITE treatment: n = 74 neurons (vehicle), 100 (ITE), from 2 mice. CH: n = 120 neurons (vehicle), 188 (CH), from 2 mice. Median and quartiles shown. Mann-Whitney two-tailed test. f , Cultures of neonatal cortical neurons. Mean longest neurite from n = 19 random fields for vehicle, 22 for ITE, 20 for CH, and 22 for SR1 across independent cultures from 2 mice. Violin plots show median and quartiles. One-way ANOVA with Dunnett’s correction. g-i , Paradigm of induced neurons (iNs) derivation and AhR agonist/antagonist treatment ( g ). IF images show Norisoboldine (Nor) treatment reduced neurite length, whereas CH-223191 (CH) enhanced outgrowth ( h ). n = 83 (Veh), 90 (Nor), and 106 (CH) cells. One-way ANOVA with Dunnett’s correction. Violin plots show median and quartiles. Box plots of neurite length (median and quartiles) after 18 hr of treatment ( i ). n = 70 –116 neurons. Highlighted conditions (Nor, CH) correspond to ( h ). Kruskal-Wallis test with Dunn’s correction; only significant P values shown. j , Left, schematic of high-throughput screen for neurite growth-promoting compounds in adult cortical neurons (Sefiani et al. ). Right, quantification of AhR antagonist SR1 effects on neurite growth. Each data point represents mean of >150 neurons (with neurites ≥ 10 μm) from a single well. n = 2–6 wells per group. Mean ± s.e.m. Unpaired two-tailed Student’s t -test. Data are mean ± s.e.m.

    Journal: Nature

    Article Title: AhR inhibition promotes axon regeneration via a stress–growth switch

    doi: 10.1038/s41586-026-10295-z

    Figure Lengend Snippet: a , STRING analysis of protein-protein interaction network of transcription factors (TFs) induced after conditioning lesion of DRG. b , qRT-PCR of AhR target genes in DRGs from adult mice treated with ITE (10 mg/kg i.p.) or vehicle. n = 3 DRGs from 3 mice. Unpaired two-tailed t -test. c , qRT-PCR shows downregulation of AhR target genes 48 h after siRNA knockdown of Ahr . n = 3 cultures for Cyp1b1 , n = 4 for the rest. Unpaired two-tailed t -test. d , Heatmap of Ahr , Arnt , and Hif1a expression across cell types of the mouse nervous system. e , IF of adult primary DRG neurons for TUJ1 + neurites. ITE treatment: n = 74 neurons (vehicle), 100 (ITE), from 2 mice. CH: n = 120 neurons (vehicle), 188 (CH), from 2 mice. Median and quartiles shown. Mann-Whitney two-tailed test. f , Cultures of neonatal cortical neurons. Mean longest neurite from n = 19 random fields for vehicle, 22 for ITE, 20 for CH, and 22 for SR1 across independent cultures from 2 mice. Violin plots show median and quartiles. One-way ANOVA with Dunnett’s correction. g-i , Paradigm of induced neurons (iNs) derivation and AhR agonist/antagonist treatment ( g ). IF images show Norisoboldine (Nor) treatment reduced neurite length, whereas CH-223191 (CH) enhanced outgrowth ( h ). n = 83 (Veh), 90 (Nor), and 106 (CH) cells. One-way ANOVA with Dunnett’s correction. Violin plots show median and quartiles. Box plots of neurite length (median and quartiles) after 18 hr of treatment ( i ). n = 70 –116 neurons. Highlighted conditions (Nor, CH) correspond to ( h ). Kruskal-Wallis test with Dunn’s correction; only significant P values shown. j , Left, schematic of high-throughput screen for neurite growth-promoting compounds in adult cortical neurons (Sefiani et al. ). Right, quantification of AhR antagonist SR1 effects on neurite growth. Each data point represents mean of >150 neurons (with neurites ≥ 10 μm) from a single well. n = 2–6 wells per group. Mean ± s.e.m. Unpaired two-tailed Student’s t -test. Data are mean ± s.e.m.

    Article Snippet: SR1 (TargetMol T1831) and vehicle were added at the time of plating and left in the medium for 2 days without medium change.

    Techniques: Quantitative RT-PCR, Two Tailed Test, Knockdown, Expressing, MANN-WHITNEY, High Throughput Screening Assay

    a, b , Long-term neuronal Ahr cKO paradigm ( a ). Tamoxifen (100 mg/kg i.p., daily x 5) was administered 14 months before sciatic nerve crush. IF of SCG10 + axons at 3 dpi shows enhanced regeneration in cKO mice compared to controls ( b ). Regeneration index: two-way ANOVA with Bonferroni correction; maximal axon length distal to lesion centre: n = 5 control, n = 6 cKO; unpaired two-tailed t -test. c , Post-injury Ahr cKO paradigm. Tamoxifen (100 mg/kg i.p., daily x 3) was administered immediately after sciatic nerve crush. At 3 dpi, SCG10 + axon regeneration was comparable between cKO and control mice (n = 5 per group). Regeneration index: two-way ANOVA with Bonferroni correction; maximal axon length distal to lesion centre: unpaired two-tailed t -test. d , Post-injury AhR antagonist treatment. SR1 (25 mg/kg), BAY-2416964 (25 mg/kg), or vehicle (DMSO) were administered daily x 3 immediately after sciatic nerve crush. At 3 dpi, IF of SCG10 + axons showed no significant differences between groups. n = 6 mice (DMSO, SR1), n = 7 (BAY). One-way ANOVA with Dunnett’s correction. Data are mean ± s.e.m.

    Journal: Nature

    Article Title: AhR inhibition promotes axon regeneration via a stress–growth switch

    doi: 10.1038/s41586-026-10295-z

    Figure Lengend Snippet: a, b , Long-term neuronal Ahr cKO paradigm ( a ). Tamoxifen (100 mg/kg i.p., daily x 5) was administered 14 months before sciatic nerve crush. IF of SCG10 + axons at 3 dpi shows enhanced regeneration in cKO mice compared to controls ( b ). Regeneration index: two-way ANOVA with Bonferroni correction; maximal axon length distal to lesion centre: n = 5 control, n = 6 cKO; unpaired two-tailed t -test. c , Post-injury Ahr cKO paradigm. Tamoxifen (100 mg/kg i.p., daily x 3) was administered immediately after sciatic nerve crush. At 3 dpi, SCG10 + axon regeneration was comparable between cKO and control mice (n = 5 per group). Regeneration index: two-way ANOVA with Bonferroni correction; maximal axon length distal to lesion centre: unpaired two-tailed t -test. d , Post-injury AhR antagonist treatment. SR1 (25 mg/kg), BAY-2416964 (25 mg/kg), or vehicle (DMSO) were administered daily x 3 immediately after sciatic nerve crush. At 3 dpi, IF of SCG10 + axons showed no significant differences between groups. n = 6 mice (DMSO, SR1), n = 7 (BAY). One-way ANOVA with Dunnett’s correction. Data are mean ± s.e.m.

    Article Snippet: SR1 (TargetMol T1831) and vehicle were added at the time of plating and left in the medium for 2 days without medium change.

    Techniques: Control, Two Tailed Test

    a , Contusion injury parameters with impactor device. n = 17 control and 14 cKO mice. Unpaired two-tailed t -test. b , IF for reactive astrocyte marker GFAP (n = 4 mice/group) and matrix proteoglycan CSPG (antibody clone CS-56, n = 3) at 35 dpi after SCI show comparable lesion size. Unpaired two-tailed t -test. c , In vivo administration of AhR antagonist SR1 starting at 1 day post-SCI (25 mg/kg i.p., daily). d , Parameters of contusion injury with impactor device in SR1 (n = 14) and control (n = 12) cohorts. Mean ± s.e.m. unpaired two-tailed t -test. e , BMS scores show improved locomotor recovery with post-injury SR1 treatment after SCI. n = 12 mice/group. Two-way ANOVA with Bonferroni correction. Ladder walking and von Frey filament testing were performed at baseline and 35 dpi. Data represent mean ± s.e.m.; unpaired two-tailed t -test. f , Diagram: AhR is sequestered in cytoplasm by two Hsp90 chaperones, p23 and XAP2. Ligand binding triggers dissociation of complex and AhR nuclear translocation. g , mRNA reads from RNA-seq analysis of ipsi- and contralateral sciatic DRGs. n = 5 samples/condition. Unpaired two-tailed t -test. h , Time-course qRT-PCR of sciatic DRGs at 12 h and 36 h post-PL. n = 4 samples/condition. One-way ANOVA with Dunnett’s correction. i , Overview of tryptophan metabolism/kynurenine pathway: IDO, indoleamine 2,3 dioxygenase; TDO, tryptophan-2,3-dioxygenase; KYAT1, kynurenine amino transferase1; KMO, kynurenine 3 monooxygenase; KYNU, kynureninase. j , mRNA reads from RNA-seq of ipsi- and contralateral sciatic DRGs. n = 5/condition. Unpaired two-tailed t -test. k , Time-course qRT-PCR of axotomized DRGs. n = 3/condition. One-way ANOVA with DEunnett’s correction. Data are mean ± s.e.m.

    Journal: Nature

    Article Title: AhR inhibition promotes axon regeneration via a stress–growth switch

    doi: 10.1038/s41586-026-10295-z

    Figure Lengend Snippet: a , Contusion injury parameters with impactor device. n = 17 control and 14 cKO mice. Unpaired two-tailed t -test. b , IF for reactive astrocyte marker GFAP (n = 4 mice/group) and matrix proteoglycan CSPG (antibody clone CS-56, n = 3) at 35 dpi after SCI show comparable lesion size. Unpaired two-tailed t -test. c , In vivo administration of AhR antagonist SR1 starting at 1 day post-SCI (25 mg/kg i.p., daily). d , Parameters of contusion injury with impactor device in SR1 (n = 14) and control (n = 12) cohorts. Mean ± s.e.m. unpaired two-tailed t -test. e , BMS scores show improved locomotor recovery with post-injury SR1 treatment after SCI. n = 12 mice/group. Two-way ANOVA with Bonferroni correction. Ladder walking and von Frey filament testing were performed at baseline and 35 dpi. Data represent mean ± s.e.m.; unpaired two-tailed t -test. f , Diagram: AhR is sequestered in cytoplasm by two Hsp90 chaperones, p23 and XAP2. Ligand binding triggers dissociation of complex and AhR nuclear translocation. g , mRNA reads from RNA-seq analysis of ipsi- and contralateral sciatic DRGs. n = 5 samples/condition. Unpaired two-tailed t -test. h , Time-course qRT-PCR of sciatic DRGs at 12 h and 36 h post-PL. n = 4 samples/condition. One-way ANOVA with Dunnett’s correction. i , Overview of tryptophan metabolism/kynurenine pathway: IDO, indoleamine 2,3 dioxygenase; TDO, tryptophan-2,3-dioxygenase; KYAT1, kynurenine amino transferase1; KMO, kynurenine 3 monooxygenase; KYNU, kynureninase. j , mRNA reads from RNA-seq of ipsi- and contralateral sciatic DRGs. n = 5/condition. Unpaired two-tailed t -test. k , Time-course qRT-PCR of axotomized DRGs. n = 3/condition. One-way ANOVA with DEunnett’s correction. Data are mean ± s.e.m.

    Article Snippet: SR1 (TargetMol T1831) and vehicle were added at the time of plating and left in the medium for 2 days without medium change.

    Techniques: Control, Two Tailed Test, Marker, In Vivo, Ligand Binding Assay, Translocation Assay, RNA Sequencing, Quantitative RT-PCR